Alzheimer's Disease Archive

It's no secret that alcohol affects our brains. Although excessive drinking is linked to an increased risk of dementia, decades of observational studies have indicated that moderate drinking has few ill effects. However, a recent British study seems to have bad news for moderate drinkers.

On call

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Q. I've noticed recently that I sweat excessively, regardless of the temperature. Should I be concerned?

A. Your genes can determine whether you sweat a lot, but a sudden change in your regular sweating may suggest an underlying condition. Sweating is regulated by your nervous system and can be triggered by a number of causes. The primary signal for perspiration originates in the brain in response to a temperature-related or emotional cue, and then is carried by the autonomic nervous system to the sweat glands in the skin.

A Harvard Medical School doctor answers a common eyesight question

Q: Recently, I started to notice tiny threadlike shapes in my field of vision. My doctor says they are "floaters." Should I be concerned?

A: "Floaters" is a catchall term for what look like dots, threads, or cobwebs drifting across your line of vision.

If you suffer from anxiety, the constant, nagging feelings of worry can be troubling and hard to control. These feelings are usually intense and out of proportion to the actual troubles and dangers in your everyday life. They can make it hard to function at home, at work, or in social situations.

Anxiety can be treated with medication, but several mind-body approaches may also be effective.

Ask the doctor

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Q. Several years ago you wrote about a new technology called CRISPR that might make it possible to cure some incurable diseases. I keep hearing about this in the news. Is it any closer to reality?

A. Yes, there has been progress. What does CRISPR stand for? You don't want to know. What does it do? You do want to know, because it's pretty amazing. A colleague here at Harvard Medical School, Dr. George Church, says CRISPR enables a scientist to "edit any piece of any DNA a thousand times more easily and precisely than before, which is game-changing for gene therapies." Why would doctors and scientists want to "edit" DNA? Because disease is caused by genes that are not built properly or are not turned on and off properly. Both problems, theoretically, can be corrected by precisely editing the DNA that makes up those genes.

Harvard research suggests meaningful relationships are a prescription for better emotional, mental, and physical health.

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You probably know there are many ways to improve your well-being and chances of living longer, such as exercising more or eating better. But did you know that maintaining meaningful relationships also may play an important role in health, happiness, and longevity? "Good, close relationships appear to buffer us from the problems of getting old," says Dr. Robert Waldinger, a psychiatrist with Harvard-affiliated Massachusetts General Hospital.

Eight decades of research

Dr. Waldinger is the current director of the Harvard Study of Adult Development, an ongoing analysis that's followed more than 700 men since they were teenagers in 1938. More than 60 of the original participants, now in their 90s, are still taking part.

If you have a hacking cough and breathlessness, don't chalk it up to aging.

Maybe you never smoked, or you stopped decades ago. But you may still be at risk for chronic obstructive pulmonary disease (COPD). That's the umbrella term for a number of lung diseases that sometimes lead to disability and even death. "While about 80% of COPD cases are related to having smoked, 20% are not," says Dr. Bartolome Celli, a pulmonologist with Harvard-affiliated Brigham and Women's Hospital.

Diseases and symptoms

COPD includes emphysema, chronic bronchitis, severe asthma, or a combination of these conditions. They cause inflammation, destruction, or abnormal repair of airways and lung tissue, which reduces airflow and ultimately makes it harder to take in enough oxygen to supply the body.

A rapid heartbeat can be frightening, but this often-fleeting problem is usually harmless.

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If you're exercising or feeling very nervous, you expect your heart to beat faster than normal. But what if your heart sometimes starts racing out of the blue, for no apparent reason? You might have supraventricular tachycardia, or SVT. SVT is an umbrella term that covers several different types of rapid heart rhythms, all of which are caused by an electrical glitch in the upper part of the heart.

The most common SVTs are atrial fibrillation — a rapid, chaotic rhythm that increases the chance of having a stroke—and atrial flutter, a fast but usually regular heartbeat. But when cardiologists talk about SVT, they're usually referring to three different, less-common conditions (see "What is supraventricular tachycardia?").

By the time memory loss shows up, the disease is well under way. Researchers are finding ways that may reveal brain changes sooner.

For a long time, memory loss was seen as the telltale sign of Alzheimer's disease. While this is certainly the most common symptom, it may not be the best way to identify the disease in its early stages.

"A major problem of Alzheimer's diagnosis, and ultimately effective treatment, is that by the time the first clinical symptoms appear, irreversible damage to the brain has already occurred," says Dr. Seth Gale, a neurologist with Harvard-affiliated Brigham and Women's Hospital. "It is now believed that Alzheimer's-related changes begin in the brain at least a decade before any symptoms emerge."