Brain health Archive

Research we're watching

Mentally engaging activities have been long been promoted for staving off dementia, but there isn't a lot of information about whether doing them late in life is effective in preventing mild cognitive impairment (MCI), a precursor of dementia. To help fill that gap, researchers from the Mayo Clinic Study of Aging followed 956 men and 973 women ages 70 or older who had normal scores on mental function tests. The participants answered periodic questionnaires detailing whether and how often they read books, did craft projects, used a computer, played games, and engaged in social activities like going out to movies and plays. They also underwent neurologic exams and completed tests to assess mental function. Over an average of four years, 456 participants developed mild cognitive impairment.

When the researchers analyzed the results, they found that playing games, doing craft projects, using a computer, and engaging in social activities were associated with a significant reduction in the risk of developing mild cognitive impairment.

Author and migraine sufferer Joan Didion once wrote, "That no one dies of migraine seems, to someone deep into an attack, an ambiguous blessing." At that time, migraines weren't something that could be prevented. Today, that's a possibility for some people who have severe migraines, frequent migraines (more than three or four times a month), or migraines that don't respond well to treatment.

The cornerstone of migraine prevention is managing triggers like stress or certain foods or strong perfumes. Alternative and complementary therapies (like acupuncture) help some migraine sufferers keep headaches at bay.

Early treatment of the most common type of stroke, ischemic stroke, can limit brain damage and vastly improve outcomes. Ischemic stroke is the kind caused by atherosclerosis, which causes blood clots that block the blood supply to a part of the brain. Yet too few ischemic stroke patients receive important clot-busting drugs, which are most effective when given within three hours after symptoms start. Patients often arrive at the hospital after that window of opportunity has closed. They delay getting treatment because stroke symptoms may not be that pronounced or they are mistaken as coming from other, less serious problems.

As a result, doctors are looking for ways to make it easier for the layperson to identify a stroke. The Cincinnati Prehospital Stroke Scale is one such attempt. Some experts say it leaves out too many symptoms. Others say it will cause false alarms because it's not specific enough..

Most people with atrial fibrillation take anti-clotting drugs to prevent strokes. For those who cannot take these drugs because of a high risk of bleeding, a tiny, basket-like device implanted in the part of the heart that traps clots may be an alternative. 

Vascular dementia is a less prevalent type of memory loss that nonetheless affects many older men.

 Image: Mike Watson Images/Thinkstock

While Alzheimer's disease continues to be the most recognized type of dementia, older men should also be mindful about the second most common: vascular dementia.

In vascular dementia, memory problems result from damage to large and small blood vessels in the brain. It develops when cholesterol-clogged blood vessels can't deliver enough oxygen to the brain. Small blockages deprive some brain cells of oxygen, which causes a series of small strokes that kill brain cells. This can lead to episodes of confusion, slurred speech, and problems thinking or remembering.

Older adults who report feeling lonely had a greater risk of testing positive for high amyloid levels in the brain, a marker of Alzheimer’s disease, according to research from the Harvard Aging Brain Study.

By now it’s evident that healthy lifestyle habits have clear benefits, and evidence suggests that keeping Alzheimer’s disease at bay may eventually be added to the list. Data are strongest for regular exercise, a Mediterranean diet, and sufficient sleep as important ways to reduce the risk of Alzheimer’s. Other lifestyle choices may help as well.

Lacunar strokes, which account for about one-fifth of all strokes, occur in small arteries deep within the brain. Although these strokes may not cause symptoms, those that do may cause weakness in the face, arm, or leg on one side of the body. 

In an observational study of 1.3 million women, excess weight was linked to an increased risk of strokes caused by blood clots but a lower risk of strokes caused by bleeding. 

The FDA has approved use of a clot-retrieving device along with a clot-busting drug on stroke patients, as long it’s within six hours of the onset of stroke symptoms.