Digestive Health Archive

They affect more women, but men still are at risk.

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Most people never think about gallstones—that is until they experience the severe, gut-piercing pain of a gallstone attack. "These often strike after eating, especially a high-fat or high-cholesterol meal, and can last about 30 minutes to two or more hours," says Dr. William Brugge, past director of gastrointestinal endoscopy at Harvard-affiliated Massachusetts General Hospital.

The attacks often begin in the upper-right side of the abdomen and may spread to the back, between the shoulder blades, and under the right shoulder. Nausea or vomiting may also occur.

It appears people with the highest levels of physical activity have lower rates of cancer of the esophagus, lung, kidney, colon, head and neck, rectum, bladder and breast, compared with people with the lowest levels of physical activity.

A group of scientists wants to develop technology to create a synthetic human genome, which could lead to improved organ transplantation, vaccines and medicines, and to new ways to fight cancer and infections.

It appears that four healthy habits—getting 150 minutes of moderate-intensity exercise per week, maintaining a body mass index between 18.5 and 27.5, no smoking, and drinking only in moderation—may prevent many cancer cases and death in white people.

News Briefs

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A Harvard study published March 3, 2016, in JAMA Oncology adds to increasing evidence that aspirin use may help stave off colorectal cancer and suggests that aspirin is also associated with a small reduction of overall cancer risk.

Researchers looked at aspirin use among almost 136,000 men and women in two studies over 32 years. They noted that regular aspirin use—taking either a 325-mg tablet or an 81-mg tablet two or more times per week—was associated with a 3% reduction in cancers over all, although they saw no effect on major cancers like those of the breast, prostate, or lung. The researchers say the overall reduction was due mostly to a 15% risk reduction for gastrointestinal cancer and a 19% risk reduction for colorectal cancer.

Many men with prostate cancer benefit from active surveillance, in which treatment doesn’t begin unless the cancer spreads. There has been some debate about whether this strategy is safe for men with intermediate-risk prostate cancer. A new study suggests that this type of cancer is more likely to spread than previously thought — but active surveillance can still be a good option for many intermediate-risk men.

Hiccups are often caused by many everyday situations, including distention of the stomach (which can be the result of overeating), swallowing air, or drinking carbonated beverages. They usually go away on their own, but episodes that last longer than 48 hours could be a sign of certain medical problems. 

Proton-pump inhibitors are among the most-prescribed medications, but is long-term use safe?

Proton-pump inhibitors reduce stomach acid, which helps to treat symptoms of acid reflux.
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Proton-pump inhibitors (PPIs), which are used to treat a variety of gastrointestinal problems, are among the most popular drugs in the United States. In fact, the FDA estimates about one in 14 Americans has used a PPI.

It may be time to re-evaluate if it's been a while since you started using proton-pump inhibitors.

Long-term use of some heartburn medications appears to be associated with an increated risk of dementia, heart attack, and chronic kidney disease. 
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You may think you're reaching for heartburn relief when you take a proton-pump inhibitor (PPI), a type of medication that helps block the production of stomach acid. PPIs are effective, and some—such as lansoprazole (Prevacid) and omeprazole (Prilosec)—are readily available over the counter. Others, such as pantoprazole (Protonix), are frequently prescribed for long-term use. But PPIs may have risks when taken over a long period.