Medication side effects Archive

Rheumatoid arthritis (RA) affects two to three times as many women as men. Scientists are uncovering RA's potential genetic and hormonal underpinnings, which point to potential reasons why women are more vulnerable. The newest treatments, called Janus kinase (JAK) inhibitors, resulted from research that has teased out delicate differences in immune system pathways. They block numerous proteins that ramp up inflammation fundamental to RA. The wide array of drug options now available for RA help doctors personalize therapies to each patient.

Having an extremely low LDL level from aggressive cholesterol-lowering therapy was not associated with cognitive impairment, according to a 2024 study.

There's no clear-cut answer about whether taking antihistamines for allergies increases dementia risk. Antihistamines have anticholinergic effects, which might increase the risk for dementia by blocking a particular brain neurotransmitter or increasing brain inflammation. But studies on whether there's any link between antihistamines and dementia have produced conflicting findings. Doctors advise taking the lowest antihistamine dose possible or using another medication for symptom relief.

High levels of Lp(a)—a fatty particle similar to LDL cholesterol—may double or triple a person’s risk of a heart attack. About one in five adults may have elevated levels, which also raises the risk of stroke and aortic stenosis. Unlike LDL, which rises with age and is influenced by diet and exercise, Lp(a) remains largely constant over a person’s lifetime, so a one-time test suffices for screening. Lp(a) testing is becoming more common now that five promising new Lp(a) therapies are in development.

After a heart attack or stent placement, people typically take a combination of aspirin and another antiplatelet drug. After one year, the new standard practice is to stop the aspirin, in contrast to the previous practice of stopping the other drug.

The two main side effects caused by statins are muscle aches (which disappear once the drug is stopped) and a higher risk of diabetes (which is most common in people with obesity and prediabetes).

A 2024 analysis of 137 studies involving almost 90,000 people found that older drugs called triptans are more effective at stopping migraine pain in a moment of agony, compared with newer medications such as ditans and gepants.