Skin Cancer Archive

Research we're watching

Move your body more and skip the alcohol to reduce your risk of cancer, says the American Cancer Society in its new cancer prevention guidelines. The updated recommendations, published online June 9, 2020, by CA: A Cancer Journal for Clinicians, also recommend cutting down on sugar and red meat, based on a review of the most recent scientific evidence.

Specifically, the new guidelines say that instead of exercising moderately for 150 minutes a week or doing 75 minutes of vigorous activity, adults should try to squeeze in 150 to 300 minutes of moderate activity or 75 to 150 minutes of vigorous activity — and that the higher number should be the target. As for diet, people interested in reducing their risk of cancer should aim to eat more plants, including whole (not refined) grains and at least two-and-a-half cups of colorful fruits and vegetables each day, and less sugar and meat (specifically limiting processed and red meat whenever possible). In the past, the ACS recommended moderate alcohol intake, but the new guideline says it's better to avoid alcohol altogether if possible. People who do drink should still stick to the previous recommended limits: no more than one drink a day for women and two drinks a day for men.

Blood testing to detect early cancer may be closer to reality than ever before.

When it comes to most cancers, the sooner they're found, the better. "Identifying cancer in its earlier stages offers improved chances for treating it before it can grow and spread," says Dr. Brian Wolpin, director of the Gastrointestinal Cancer Center at Harvard-affiliated Dana-Farber Cancer Institute.

Unfortunately, there are not reliable tools to screen for most cancers. Examples of effective screening tests that do exist now include colonoscopies that look for polyps and early colorectal cancers, as well as imaging tests like mammograms for early signs of breast cancer and chest CT scans for localized lung cancer among former or current smokers.

News briefs

First it was certain blood pressure and heartburn drugs; now some medications used to treat type 2 diabetes are being recalled because of cancer concerns. The FDA warned in late May and early June 2020 that some lots of extended-release metformin may contain unacceptable levels of N-nitrosodimethylamine (NDMA), a possible cancer-causing chemical. At least five manufacturers are now issuing voluntary recalls of the medications. But if you take extended-release metformin, don't just stop on your own. Not all extended-release metformin products are affected by the voluntary recalls, and stopping any medication that controls blood sugar can be very dangerous. The FDA advises that you check in with your doctor or pharmacist. Ask if your medication is affected by the recall; if so, ask if you should switch to another version of the drug.

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Make the most of your skin barrier to ward off certain types of disease. Hint: It pays to moisturize.

Picture it: You're the body's military commander, and you're reviewing your protective forces. Immune system? Check. Stomach acid? Check. Beneficial gut bacteria? Check.

Don't forget to include your skin: it's one of the most important bastions in the fight against disease, keeping harmful organisms and substances from getting inside the body.

Research we're watching

A new tool to identify people who might be at higher risk for pancreatic cancer could help doctors find cases earlier, when they are most treatable. Researchers from the Harvard T.H. Chan School of Public Health created a risk model that did a better job than current models of finding people at high risk for the disease. It takes into account clinical and genetic factors as well as blood levels of biomarkers (substances that could potentially indicate disease). To test the model researchers used data from four large clinical studies. They applied the tool to 500 known pancreatic cancer patients and more than 1,000 people without cancer. The researchers then assessed how well the tool would have predicted the risk of pancreatic cancer. Pancreatic cancer, which is the third leading cause of cancer death in the United States, is challenging to treat because most people already have advanced disease when they are diagnosed. It's hoped that identifying people who are at high risk will eventually allow doctors to screen these individuals to find cancers when they are smaller and more curable.

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In the journals

Scientists continue to explore the health benefits versus risks of aspirin therapy. One new analysis suggests that taking aspirin may protect against several types of digestive tract cancers. The results were published online April 1, 2020, by Annals of Oncology.

Researchers examined 113 observational studies of cancer in the general population. They found that individuals who took aspirin regularly — at least one or two tablets a week — had significantly lower rates of cancers of the bowel, stomach, gallbladder, esophagus, pancreas, and liver, compared with people who did not take aspirin.

Research we're watching

While more than three-quarters of Americans say that sun protection is important, less than half actually use it on a regular basis when they're heading outside, according to a survey by the American Academy of Dermatology. Some 28% of those polled said they rarely or never use sun protection, which includes using sunscreen, staying in the shade outside whenever possible, and wearing clothing such as hats or other items that can protect against the sun's rays. Sun exposure is the leading cause of skin cancers, affecting one in every five Americans, so the AAD says it's important that people take steps to protect themselves. The AAD recommends that you

• wear sunscreen with 30 SPF or higher
• stay out of the sun between 10 a.m. and 2 p.m., when its rays are the most intense
• use clothing to protect your skin, such as a hat and long-sleeved shirt.

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Tips to help you treat this common skin condition.

You thought you left acne behind you in your teen years, but here you are at midlife with a breakout. But it might not be what you think. Rosacea is often mistaken for acne, and the condition, which most often begins after age 30, sometimes flares at menopause, says Dr. Suzanne Olbricht, an associate professor of dermatology at Harvard Medical School.

A common skin condition affecting some 16 million Americans, rosacea most often develops in people with fair skin who blush easily. Rosacea is sometimes mistaken for sunburn, a naturally ruddy complexion, or even an allergic reaction. It produces a number of skin problems, including

Research we're watching

If you suffer from the common skin condition eczema, you may have a higher risk of breaking a bone compared with someone who doesn't have the condition, according to a study published in the February 2020 issue of The Journal of Allergy and Clinical Immunology. The study authors found that the 500,000 people in the study who had eczema, which causes itchy dry patches on the skin, were 7% to 18% more likely to break a bone in the wrist, hip, pelvis, or spine when compared with more than 2.5 million participants who didn't have the condition. Researchers said it's not clear if this elevated fracture risk was related to the eczema itself or whether other factors caused the association. For example, the increase in risk could have been related to medications people took to treat eczema. Even so, if you have eczema, the study authors say it may be worth asking your doctor whether you might be at increased risk for osteoporosis.

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