Alzheimer's Disease Archive

News briefs

A research team from Harvard reports that it has harnessed the powerful gene editing tool called CRISPR to recognize and kill viruses. The findings were published online Oct. 2, 2019, by Molecular Cell. CRISPR can alter strands of both DNA and RNA (a molecule related to DNA), which are built like strings of beads. Each bead consists of one of four chemicals called bases. CRISPR can recognize a specific sequence of bases (such as one that is characteristic of a particular virus), latch on to that sequence and cut it, and change the sequence to a different one. This can scramble the genetic sequence of a virus in such a way that the virus no longer can make copies of itself. The Harvard team used this technique to kill several viruses that are made of RNA — including influenza virus — in a laboratory dish. The next step will be to see if the CRISPR technique can also be used to kill viruses in a living animal. That will be much harder. However, if it works, the technique might someday help humans fight viral infections.

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Research we're watching

If you suffer from migraine headaches, there's a new option available to relieve your pain. In October 2019, the FDA approved lasmiditan (Reyvow) to treat migraine pain in adults. Taken as a pill, it works for migraines either with or without an aura (a visual disturbance within the hour before migraine pain starts). Lasmiditan is not designed to prevent migraines. Lasmiditan is the first migraine treatment in a class of drugs known as serotonin (5-HT) 1F receptor agonists. In studies, researchers found that it could relieve pain and other migraine symptoms within two hours.

Migraines affect an estimated 28 million women in the United States, according to the American Migraine Foundation, and the World Health Organization ranks them among the top 10 disabling conditions. Pain and other symptoms, which may include nausea, sensitivity to light and temporary vision changes, result in lost work days, reduced productivity, and diminished quality of life for many people.

These tips can help you recall the details from past events and learn from them.

Does this sound familiar? You can't recall the name of someone you met before. Or you forget the time-saving shortcut from a previous car trip. Or you repeatedly make the same silly mistake doing a once-familiar task.

It's frustrating when you can't recall certain past details. You may chalk it up to "senior moments." But, the actual problem is a breakdown in your episodic memory, the brain's largest and most complex memory system.

In the journals

Over-the-counter pain medicines that contain caffeine can be effective at stopping some headaches. But drinking a large amount of caffeinated beverages might actually trigger a headache for some people with migraines, according to a study published in the August 2019 issue of The American Journal of Medicine.

Researchers recruited almost 100 people with migraines who suffered from fewer than 15 headaches per month. For six weeks, they recorded the timing and characteristics of each migraine and their intake of caffeinated beverages.

Eosinophilic esophagitis is an allergic inflammation of the esophagus that most typically develops as an allergic response to certain foods. The exact cause is unclear, but if left untreated it can lead to permanent scarring or narrowing of the esophagus.

Although hard-to-read heart attacks happen to both men and women, they are more common in women. One reason for this is that men's symptoms initially set the standard for recognizing heart trouble. Now a growing body of research shows that women can experience heart attacks differently than men.

Understanding sex differences in heart disease is important. Heart disease is the leading cause of death for women. Although it mostly affects older women, it isn't rare in younger women. One in 10 of all women who die from heart disease or a stroke are under age 65, and this age group accounts for one-third of heart- or stroke-related hospitalizations. Even so, younger women and their doctors don't necessarily suspect a heart attack even when all the signs are there.

Take the lowest dose of NSAIDs and stop using them as soon as possible.

Blood thinners are usually given to people at risk for developing blood clots from conditions, such as abnormal heart rhythms. Use of these lifesaving medications requires caution with other drugs, especially painkillers called nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil) or naproxen (Aleve). But plenty of people take the risk to relieve aches and pains. "Many of the patients who need blood thinners are older and therefore at risk for arthritis, so it's not infrequent for a patient to be on both a blood thinner and an NSAID," says cardiologist Dr. Deepak L. Bhatt, a Harvard Medical School professor.

Semantic memory is your store of factual knowledge and the meanings of words. It also helps you recall nonverbal concepts and relationships between words and concepts. And while some aspects of memory may decline with age, semantic memory does not.

If you’re like most people with hearing loss, you’ll probably find that it takes time to accept the idea that you need a hearing aid, and you may be unhappy when your audiologist recommends that you get not one, but two. Chances are that your first question will be, “Is it normal to get two hearing aids?” And then, “Do I really need two?”

If you have hearing loss in only one ear and normal or nearly normal hearing in the other, then one hearing aid is all you need. But most people have hearing loss in both ears, especially if the loss is age-related. (You may have one ear that’s better than the other, but chances are both will be in the same ballpark.) In that case, research and experience suggest that you’ll ultimately be more satis­fied with two hearing aids.

News briefs

Want something simple to boost your health? Try looking on the bright side. A large observational study published online Sept. 27, 2019, by JAMA Network Open tied optimism to fewer heart attacks and a lower risk for premature death. Researchers combed through 15 studies that included almost 230,000 people who were followed for an average of 14 years. Being optimistic was associated with a 35% lower risk for cardiovascular events and a 14% lower risk for an early death, compared with being pessimistic. The findings don't prove that seeing the glass half-full causes better health, but many other studies have reported similar findings. "Optimistic people may have healthier habits, such as regular exercise and healthy diets; and they may be better at regulating their emotions in stressful situations, which could also contribute to lower levels of inflammation. But we need more research to confirm it," says Dr. Laura Kubzansky, a study author and co-director of the Lee Kum Sheung Center for Health and Happiness at the Harvard T.H. Chan School of Public Health.

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