Alzheimer's Disease Archive

Ask the doctor

Q. How do we store memories in our brain, and is there hope that someday we might be able to restore memories we've lost?

A. We remember just a tiny fraction of the events of our lives. The sights and sounds of every conscious moment could become a memory. But only when a moment seems important do we remember it, at least for a while. I remember the radiant beauty of my wife's face on our wedding day, at the moment she lifted the veil.

Details of significant experiences from decades ago may still be available if you can coax them out of your memory.

Sometimes memories of certain experiences remain crystal clear for life, like the moment you said "I do," or the first time you held your baby in your arms. Other significant memories from long ago can be harder to recall. But they may still be with you; it just takes effort to retrieve them.

Which memories stay with us?

Of the many memories you accumulate every day, only those marked as meaningful are recorded in your brain's long-term files. "We have a system in our brains that tags memories that are important in some way so we'll remember them in the future," explains Dr. Andrew Budson, a neurologist and chief of Cognitive and Behavioral Neurology at VA Boston Healthcare System.

News briefs

We already know that mindfulness meditation and a mentally active life are boons to healthy aging. But do these practices also help older people struggling with mild cognitive impairment (MCI)? To find out, Harvard researchers reviewed more than a dozen recent studies that looked at the effects of either mindfulness or cognitive training (including computerized programs) on older adults with MCI. In findings published online Dec. 29, 2020, by The American Journal of Medicine, researchers concluded that both strategies have potential benefits for cognition and mood. For people with MCI, practicing mindfulness over several weeks to months seemed to sharpen attention, memory, and other mental skills, and ease anxiety and depression. Similarly, cognitive training was associated with better memory, executive function, and mood. Most of the studies included in the review were relatively small and short-term, so they don't provide strong evidence of benefit, nor could they determine how long any benefit might last. But researchers say both strategies are feasible and low-risk, with the potential to benefit thinking skills and mood in people with MCI. Now we need more research to find out how the benefits might translate into everyday life and endure over time.

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Mindfulness can help soothe short-term and chronic pain.

Your mind is a powerful pain remedy when given the chance. Science continues to show how mindfulness can manage pain — and it doesn't take years to master.

"Using mindfulness is a way for older adults to treat ongoing chronic pain and the occasional flare-up without having to always rely on medication," says Ellen Slawsby, director of pain services at Harvard-affiliated Benson-Henry Institute for Mind Body Medicine.

In the journals

People with anxiety or depression often have trouble making sound decisions. But a study suggests their judgment can improve if they focus on past successes instead of mistakes. The findings were published online Dec. 22, 2020, by the journal eLife.

Researchers recruited 86 adults, divided into three groups. In one group were people diagnosed with generalized anxiety disorder or major depression. Another group consisted of people who showed anxiety or depression symptoms, like excessive worrying and not feeling good about the future, but were not clinically diagnosed. The final group included those without anxiety or depression.

Many cases of memory loss aren't related to dementia, but stem from other, treatable conditions.

You've been forgetting things lately — your keys, or maybe names. Sometimes you struggle to find the right word in conversations or repeat yourself to others. You may worry: are these signs of dementia?

If this sounds like you, you're not alone. Many people find their way into Dr. Tammy Hshieh's office wondering the same thing. But most of the time, it's not dementia causing their problems, says Dr. Hshieh, a geriatrician at Harvard-affiliated Brigham and Women's Hospital and Dana-Farber Cancer Institute and assistant professor of medicine at Harvard Medical School.

On call

Q. I have just recovered from the flu. How soon can I resume exercise again and can I go straight back to my previous routine?

A. The recommendations about when to return to exercise after respiratory infections, such as the flu, colds, or bronchitis, are vague. One major reason is that each person's response to illness is so variable. But here is my general advice.

Can adopting a healthier diet help fight prostate cancer? That's a question men newly diagnosed with prostate cancer often ask their doctors.

Several studies have shown that in countries where men eat a typical "Western" diet containing a large amount of meat, the incidence of prostate cancer, especially aggressive prostate cancer, is higher than in countries where plant-based foods are a primary part of the diet. Unfortunately, these studies weren't designed to prove cause and effect. So for now, definitive answers about prostate cancer and diet aren't yet in — although researchers are actively studying this topic.

Ask the doctors

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Q. I've read that getting the flu shot annually will weaken my immune system over time. Is this true?

A. A study published in the March 1, 2017, issue of The Journal of Infectious Diseases investigated whether getting an annual vaccination against influenza (flu) can weaken your body's natural ability to protect itself from the disease. Past studies have raised similar concerns. Researchers at the University of Bergen in Norway followed 250 health care workers. Some of them got a flu vaccination every year from 2009 through 2013. The others only received the vaccine once in 2009 and not in the years from 2010 to 2013. The researchers then took blood samples before the influenza season (and before people were vaccinated that season), from the members of both groups and looked at different markers to gauge how well their immune systems would respond to the influenza virus. They found that getting an annual flu vaccination did not weaken the immune system. As a group, the people who got the flu shot annually appeared to have a better immune response to influenza than those vaccinated only once.