Brain health Archive

In the journals

Blood pressure readings are usually done on only one arm, but a new analysis makes the case for checking both arms, as the difference between them may suggest an elevated risk for heart disease. The findings were published in the February 2021 issue of Hypertension.

Researchers examined 24 studies that measured blood pressure in both arms in 53,827 adults without high blood pressure. They found that a difference of more than five points between the left and right arm systolic readings (the top number) was linked with a 9% higher risk for a first-time heart attack or stroke and a 6% increase in cardiovascular death within 10 years. The greater the difference between the two readings, the higher the risk.

Many cases of memory loss aren't related to dementia, but stem from other, treatable conditions.

You've been forgetting things lately — your keys, or maybe names. Sometimes you struggle to find the right word in conversations or repeat yourself to others. You may worry: are these signs of dementia?

If this sounds like you, you're not alone. Many people find their way into Dr. Tammy Hshieh's office wondering the same thing. But most of the time, it's not dementia causing their problems, says Dr. Hshieh, a geriatrician at Harvard-affiliated Brigham and Women's Hospital and Dana-Farber Cancer Institute and assistant professor of medicine at Harvard Medical School.

The shift from this condition to dementia is not necessarily inevitable.

 Image: © gradyreese/Getty Images

Will I get dementia? That common question takes on urgency if you have mild cognitive impairment (MCI), a slight but noticeable change in memory and thinking skills. But the progression from MCI to dementia is not automatic. In fact, MCI is not always permanent. "It depends on the underlying cause," says Dr. Joel Salinas, a neurologist at Harvard-affiliated Massachusetts General Hospital.

What are the causes of MCI?

MCI is not dementia (see "What is dementia?"), but it's not normal thinking, either. It often stems from disease or treatments for disease, including

Listening to music may boost exercise ability, ease stress and anxiety, and enhance recovery from strokes.

 Image: © shironosov/Getty Images

Whether you prefer Stravinsky's symphonies or the Beatles' ballads, you probably listen mostly because you simply like how they sound. You might not realize that music engages not only your auditory system but many other parts of your brain as well, including areas responsible for movement, language, attention, memory, and emotion.

"There is no other stimulus on earth that simultaneously engages our brains as widely as music does," says Brian Harris, certified neurologic music therapist at Harvard-affiliated Spaulding Rehabilitation Hospital. This global activation happens whether you listen to music, play an instrument, or sing — even informally in the car or the shower, he says. And it helps to explain how and why music therapy works (see "Singing — and striding — stroke survivors").

On call

Q. What is the significance of mild narrowing of the carotid artery detected by an ultrasound? I have never had any symptoms of stroke.

A. "Mild" narrowing ranges from 15% to 49% blockage of the artery. Over time, this narrowing can progress and lead to a stroke. Even if it doesn't progress, mild narrowing is a sign of early blood vessel disease and calls for preventive measures.

We’ve all experienced the feeling of sluggish, fuzzy thinking and a lack of sharpness, possibly caused by an illness or a medication. But what if that feeling didn’t go away and your thinking didn’t return to normal? That’s the situation for some people who have recovered from COVID-19, and there can be long-term effects on other organs as well.

it is becoming increasingly clear that COVID-19 affects the nervous system along with the respiratory system. Research is suggesting that this may result in long-term neurologic damage in those who survive a COVID infection, including evidence of effects on cognitive function.

Research we're watching

People with atrial fibrillation (afib) who consume more than 14 alcoholic beverages a week may face a higher risk of stroke and other blood clot-related problems, according to a new study.

The study included 9,411 people with afib, who were divided into four groups based on how much they typically drank per week: abstainers or rare drinkers (less than one), light drinkers (less than seven), moderate (seven to 14), and heavy (14 or more). Researchers then tracked the participants for a median follow-up period of 17.4 months, noting the incidence of strokes, transient ischemic attacks (ministrokes), blood clots in a limb or organ (embolisms), or hospitalization for management of either atrial fibrillation or heart failure.

These drugs actually help stop dangerous blood clots from forming. Here's when you may need them.

Nearly everyone has heard of "blood thinners." Maybe you or someone you know takes one. But these drugs don't "thin" blood at all.

"They are actually anti-clotting drugs," says Dr. Gregory Piazza, a cardiologist with Harvard-affiliated Brigham and Women's Hospital. "They prevent potentially dangerous blood clots from developing in people at high risk, like those who have atrial fibrillation or a stent in a blood vessel, or who are immobile after surgery."

About one in five people has high levels of lipoprotein(a), a fatty particle linked to premature heart disease.

Most people probably haven't heard of lipoprotein(a), although that's not surprising. Cardiologists have known for years that having high levels of these fatty particles circulating in the bloodstream poses a risk to the cardiovascular system. But there wasn't much they could offer in terms of therapy, so widespread testing for lipoprotein(a) — also known as Lp(a) — didn't make sense.

Recent progress means the landscape may soon be shifting. Earlier research showed that injectable cholesterol-lowering drugs known as PCSK9 inhibitors, such as evolocumab (Repatha) or alirocumab (Praluent), may lower Lp(a) by up to 25%. Until last year, however, it wasn't clear whether that reduction actually helped people with high Lp(a).