Cancer Archive

New research again links increased breast cancer risk to longer use of hormone therapy.

The link between hormone therapy and breast cancer has been recognized for years. But an analysis published Aug. 29, 2019, in The Lancet has added some additional information to the discussion. The analysis looked at 58 studies that included information on the type and timing of hormone use in individual women, and their body mass index. Researchers began gathering the studies in 1992 and continued until 2018.

We asked Dr. Wendy Chen, an assistant professor of medicine at Harvard Medical School, to help us sort through both the old and new information on hormone use and breast cancer and what it means for women considering starting hormone therapy.

Research we're watching

Doing genetic tests on all women with breast cancer, as compared with the typical practice of just testing those with a family history of the disease, is worth the extra cost, according to a study published online Oct. 3, 2019, by JAMA Oncology. The study authors say their findings should prompt the expansion of genetic testing to all women diagnosed with breast cancer. It's clear that testing breast cancer patients for genetic variants that raise breast cancer risk (such as BRCA1, BRCA2, and PALB2) would enable doctors to identify more women who carry these variants and who might benefit from preventive strategies. But researchers wondered whether doing so would be too costly. To answer that question, they used a computer model to analyze data from more than 11,000 women. They found that not only would the cost of testing all American women with breast cancer be balanced out by later savings on health care services, but also that just one year of testing could prevent an estimated 9,700 new cases of breast and ovarian cancer and 2,400 deaths.

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Here is what men need to know to minimize discomfort of a prostate biopsy and get the best results.

An analysis of studies found an association between people with psoriasis and an increased risk of developing several types of cancer. While this does not establish a definitive link, psoriasis is a relatively common condition and those who have it should be aware of its implications.

Research we're watching

Women at high risk for breast cancer might benefit from taking medication to prevent the disease, says a new recommendation from the U.S. Preventive Services Task Force (USPSTF), a national group of experts. Medications such as tamoxifen (Nolvadex), raloxifene (Evista), and aromatase inhibitors have been shown to help prevent invasive, estrogen receptor-positive breast cancer, but they can cause serious side effects, such as other cancers and blood clots. For some women, the potential benefits of these drugs outweigh those risks. The USPSTF, however, recommends against routine use of these medications for women who are not at high risk for breast cancer, because the potential benefit is much smaller. Women who are over age 35 and are at high risk for breast cancer or who have had previous benign breast lesions (such as atypical ductal or lobular hyperplasia or lobular carcinoma in situ) might want to discuss this recommendation with their doctor. The USPSTF encouraged doctors to weigh the risk of breast cancer against potential drawbacks of the medications and the individual woman's risk for adverse effects.

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Over the past decade, research has revealed that the majority of patients treated for cancer experience difficulties with memory, attention, concentration, and thinking. There are several lifestyle actions that can help improve these symptoms, as well as certain medications.

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Screening symptom-free adults for pancreatic cancer doesn't appear to reduce deaths from the disease, according to a new analysis by the U.S. Preventive Services Task Force (USPSTF). The group advises against recommending screening in this group.

Pancreatic cancer is relatively uncommon, but the prognosis for people who get it is often poor, because it is frequently found at an advanced stage. This has made it the third most common cause of deaths from cancer in the United States. It was hoped that screening for the disease would enable doctors to spot cases earlier, when they might be easier to treat. However, the USPSTF reviewed findings on pancreatic cancer screening in people without symptoms and determined that there is no evidence that screening in this group — or treating cases of pancreatic cancer found on screening tests — reduces deaths from the disease. The task force concluded that the benefits of screening do not outweigh the potential harms.

Research we're watching

Could a traumatic experience raise the risk of ovarian cancer? Researchers at the Harvard T.H. Chan School of Public Health and Moffitt Cancer Center found that women who remembered experiencing six or more symptoms of post-traumatic stress disorder (PTSD) had double the risk of later developing ovarian cancer, compared with women who had not reported PTSD symptoms. They were also more likely to develop a more aggressive form of the cancer. The researchers looked at data from more than 50,000 women who participated in the Nurses' Health Study II. Early in the study, women were asked to identify their most stressful life experience and any PTSD symptoms they had experienced following that event. Researchers then looked to see which of the women went on to develop ovarian cancer. The study, published Sept. 5 in Cancer Research, found higher cancer risk persisted even if a woman's PTSD symptoms had occurred decades in the past. Past animal research suggests that stress hormones may spur tumor growth.

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For years, the conventional wisdom about dairy is that we should be eating less of it, and when we do have any it should be low-fat or fat-free. But more recent research suggests that some full-fat dairy in our diets could in fact be beneficial, though the type of dairy still matters.

A widely-advertised facial moisturizer claims to be the best on the market — and sells for $225 per bottle. Should you buy it? Another brand offers a complete skin care regimen — but it comes in 10 different bottles of lotions and potions that all need to be applied daily. Is it worth your time?

Despite manufacturers' claims, many cosmetic products will remove more cash from your wallet than dirt and oils from your skin. You don't need an expensive or lengthy skin care routine — and the good news is, the most effective and reliable regimen is also quick and inexpensive.