Mind & Mood Archive

Subjective cognitive decline often appears before memory loss and other symptoms.

Recent research suggests that the brain changes leading to Alzheimer's disease begin many years before the onset of symptoms.

Most often the disease is not diagnosed until it exists in full force, so finding earlier changes in thinking or behavior may help scientists better understand this process.

In the journals

Many people with rheumatoid arthritis (RA) also deal with ongoing depression and anxiety related to their pain and disability. While drugs used to treat the disease help alleviate the joint pain and stiffness, a recent study suggests they may not extend to improving patients' mental health.

The findings, published online June 6, 2018, by Arthritis & Rheumatology, reviewed more than 70 clinical trials and found only a small association between various drugs used for RA, such as adalimumab (Humira), rituximab (Rituxan), abatacept (Orencia), and tocilizumab (Actemra), and mental health outcomes in patients.

Asking for help from friends and family and then engaging with your new community will get you through the transition.

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Downsizing from a large home to a smaller one is a fact of life for many older adults. The reason may be finances, health issues, or a desire to simplify your lifestyle. But making the transition can bring a host of emotions: sadness, grief, stress, or anxiety.

Understanding the triggers for these feelings and using strategies to navigate them may not change how you feel, but it may help the downsizing process go more smoothly so you can focus on your next chapter.

Research we're watching

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A new study published online June 21 by the journal Neuron links two common viruses to Alzheimer's disease. Based on data from three brain banks, researchers found that the brains of people with Alzheimer's disease had up to twice the levels of two viruses — herpesviruses 6A and 7 — compared with the brains of people who did not have dementia. The virus genes also appeared to have interacted with the human DNA in cells in the brain in ways that might have affected Alzheimer's disease risk.

Infection with these herpesviruses is very common. Up to 90% of people may be exposed to these viruses in childhood. They cause, among other things, a mild infection known as roseola, which produces a rash and a fever.

The prefrontal cortex does not fully develop until the mid-20s, which makes teenagers’ brains excellent at learning and absorbing new information, but it also makes them vulnerable to experimentation and the potential for substance use disorders.