Psoriasis Archive

A widely-advertised facial moisturizer claims to be the best on the market — and sells for $225 per bottle. Should you buy it? Another brand offers a complete skin care regimen — but it comes in 10 different bottles of lotions and potions that all need to be applied daily. Is it worth your time?

Despite manufacturers' claims, many cosmetic products will remove more cash from your wallet than dirt and oils from your skin. You don't need an expensive or lengthy skin care routine — and the good news is, the most effective and reliable regimen is also quick and inexpensive.

Using a CPAP machine is beneficial for people with obstructive sleep apnea, but if the machine isn’t kept clean it could lead to an illness. There are sanitizing systems available, but cleaning the parts by hand is just as effective.

PrEP (pre-exposure prophylaxis) is a daily medication taken to prevent HIV infection. While multiple studies show PrEP is effective, relatively few of those who might benefit are taking it. Will a 10-year initiative to reduce rates of HIV and a new formulation of PrEP help?

Approximately 1% of the population has vitiligo, a skin condition in which areas of skin lose their color. While topical treatments and light therapy help some, research with a class of medications not previously used for this condition has shown promising results.

Learn to spot an actinic keratosis before it becomes cancerous.

About 58 million people have at least one actinic keratosis (AK), a precancerous skin growth caused by too much sun exposure.

Yet most people don't see the potential danger in these lesions because they are small, with few if any annoying symptoms, and can go away almost as fast as they appear.

On call

Q. Is there any difference between sunstroke and heatstroke and are there certain signs and symptoms I should look for?

A. These two terms refer to the same condition. Heatstroke (or sunstroke) happens when the body can no longer maintain a temperature of under 105° F when exposed to hot weather. People almost always have warning symptoms before heatstroke, yet sometimes they do not pay attention, or are not able to take action.

The first accurate medical discussion of psoriasis dates back to 1801, but the disease itself is much older. In fact, its very name is borrowed from an ancient Greek word meaning an itchy or scaly condition. About 7 million Americans are plagued by this itching and scaling, and many of them have serious complications involving other organs. Although psoriasis is classified as a dermatologic disease, it doesn't start in the skin, and its damage may be more than skin deep.

Beneath it all

At a basic level, psoriasis is a disorder of the immune system. White blood cells called T-helper lymphocytes become overactive, producing excess amounts of cytokines, such as tumor necrosis factor, interleukin-2, and interferon-gamma. In turn, these chemicals trigger inflammation in the skin and other organs. In the skin, the inflammation produces three characteristic findings: widened blood vessels, accumulation of white blood cells, and abnormally rapid multiplication of keratinocytes, the main cells in the outer layer of the skin. In healthy skin, keratinocytes take about a month to divide, mature, migrate to the skin surface, and slough off to make way for younger cells. But in psoriasis, the entire process is speeded up to as little as three to five days. The result is thickened, red skin that sheds silvery scales of keratinocytes that have matured before their time (see Figure 1).

Q. I'm 63, and I've begun to notice a decline in the quality of my fingernails. They have numerous up-and-down ridges, and at the tips, they're always splitting. I've heard you can tell a lot about a person's health from the condition of her nails. What does my split nails say about mine?

A. Some changes in nails can be a sign of an underlying health problem, but the lengthwise nail ridging you describe is usually not one. It's simply a common sign of normal aging. The growth of fingernails and toenails slows as we get older, and their appearance may change. Some nails become yellowed or dull and brittle, and some or all may develop tiny longitudinal ridges. Fingernails tend to become thinner and more fragile, while toenails usually become thicker and harder.