Brain health Archive

In the journals

Previous studies have shown a link between loss of smell among older adults and risk of death within a short period — often five years or less. Now, a report published online May 21, 2019, by Annals of Internal Medicine confirmed this increased risk of death over more than a decade, as well as identifying the leading causes of death.

Researchers gave smell identification tests to 2,289 adults ages 71 to 82 (about half of whom were men). They found that those who scored low on the smell test had a 46% higher risk of dying within 10 years, and 30% within 13 years, compared with those who had a stronger sense of smell.

In the journals

Even if you believe you're in excellent health, you could still be at risk for a heart attack or stroke, suggests a study of more than 6,800 people, average age 62, published Feb. 15, 2019, in JAMA Network Open. At the study's beginning, participants rated their health as excellent, very good, good, or poor/fair. (More than half the men reported being in very good or excellent health.)

Next, everyone had a coronary artery calcium (CAC) scan, which detects plaque buildup in the arteries of the heart. The scores range from zero to 100 and higher, with zero meaning no plaque buildup is present and cardio-vascular disease risk is at its lowest.

How a healthy lifestyle can make a difference in Alzheimer’s prevention.

Alzheimer's disease, the most common form of dementia, is characterized by the accumulation of two types of protein in the brain: tangles (tau) and plaques (amyloid-beta). Eventually, Alzheimer's kills brain cells and takes people's lives.

Alzheimer’s causes

What causes Alzheimer's? We still aren't sure. "For 1% of all cases, there are three genes that determine definitively whether or not you will have Alzheimer's, and all three relate to amyloid-beta production, which in these cases is likely the cause of Alzheimer's," says Dr. Gad Marshall, associate medical director of clinical trials at the Center for Alzheimer Research and Treatment at Harvard-affiliated Brigham and Women's Hospital. "For the other 99%, amyloid and tau are closely associated with Alzheimer's, but many things may contribute to the development of symptoms, such as inflammation in the brain, vascular risk factors, and lifestyle."

Research we're watching

Contrary to observations that moderate drinking (one or two drinks per day) protects against stroke, a new study finds that stroke risk may rise with increasing alcohol intake.

The findings, which were published online April 4 by The Lancet, come from a study involving 160,000 Chinese adults who reported their drinking habits. They also were tested for gene variants common in Asian populations that cause an unpleasant flushing reaction after drinking. Only 2% of women reported drinking alcohol, compared with 33% of men, so the findings focus mainly on men.

A thunderclap headache is a sudden, extremely severe headache associated with several possible causes. It’s considered a medical emergency and should be treated as soon as possible.

Most people experience some degree of decreased memory as they get older, but memory performance is also affected by mood and sleep quality, and these are factors that can be controlled and improved.

Even short-lived, subtle stroke symptoms should be evaluated.

Imagine trying to write a note, but it feels like you're moving the pen through wet concrete. Or you suddenly can't see normally — it's as if a black curtain has dropped over one of your eyes.

If these odd symptoms last for only a few minutes, you might be tempted to brush them off and blame muscle cramps or fatigue. Don't make that mistake, says Dr. Christopher Anderson, director of Acute Stroke Services at Harvard-affiliated Massachusetts General Hospital. Both of the above scenarios are examples of a possible transient ischemic attack (TIA), commonly referred to as a ministroke. Caused by a temporary lack of blood in part of the brain, a TIA is a warning sign that you are at risk for a stroke.

News briefs

We often tell you about using aerobic exercise and a healthy diet to try to stave off dementia. But will those approaches help if you already have the slight but noticeable change in memory and thinking known as mild cognitive impairment (MCI)? A small randomized trial (the gold standard type of study) published online Dec. 19, 2018, by Neurology suggests the combination of diet and exercise may indeed help. Researchers studied 160 sedentary older adults who had MCI as well as one or more cardiovascular disease risk factors, such as high cholesterol. Participants were randomly assigned to do aerobic exercise, to follow a heart-healthy diet (the Dietary Approaches to Stop Hypertension, or DASH, diet), to do a combination of aerobic exercise and the DASH diet, or to just get weekly heart health education. After six months, people who just exercised several times a week got a little bump in executive function (thinking skills that help us plan and organize), but the biggest change was seen in people who both followed the DASH diet and did aerobic training three times a week. Their improved planning skills were equivalent to reversing nearly 10 years of brain aging, compared with study participants who didn't exercise or improve their diets. The findings demonstrate that it's never too late to start exercising and eating right.

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Learn how to recognize and prevent this dangerous condition, known as venous thromboembolism, or VTE.

When a blood clot blocks an artery supplying the heart or the brain, the result is a heart attack or stroke. Most Americans are familiar with these two serious health threats. But they're probably less familiar with the dangers of venous thromboembolism, or VTE — a clot that forms in a vein.

A clot in the leg or arm, known as deep-vein thrombosis, can cause pain, swelling, and redness in the affected limb. But the real threat occurs if the clot breaks off and travels to the lungs, causing a pulmonary embolism.